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Friday, July 31, 2020 | History

7 edition of Modeling for preparative chromatography found in the catalog.

Modeling for preparative chromatography

by Georges Guiochon

  • 9 Want to read
  • 22 Currently reading

Published by Academic Press in Amsterdam, Boston .
Written in English

    Subjects:
  • Chromatographic analysis -- Mathematical models.,
  • Separation (Technology)

  • Edition Notes

    Includes bibliographical references and index.

    StatementGeorges Guiochon, Bingchang Lin.
    ContributionsLin, Bingchang.
    Classifications
    LC ClassificationsQD79.C4 G85 2003
    The Physical Object
    Paginationx, 342 p. :
    Number of Pages342
    ID Numbers
    Open LibraryOL3319695M
    ISBN 100120449838
    LC Control Number2004271245
    OCLC/WorldCa52475964

    Chromatography has long been, and remains, the workhorse of downstream processing in the production of biopharmaceuticals. As bioprocessing has matured, there has been a growing trend toward seeking a detailed fundamental understanding of the relevant unit operations, which for some operations include the use of mechanistic modeling in a way similar to its use in the conventional chemical. ISBN: OCLC Number: Description: x, pages: illustrations ; 25 cm: Contents: Machine derived contents note: Table of contents for Modeling for preparative chromatography / Georges Guiochon, Bingchang Lin. --Bibliographic record and links to related information available from the Library of Congress catalog --Information from electronic data provided .

    Article DetailsBioPharm International Vol. 30, No. 4 Pages: 41–45 Citation: When referring to this article, please cite it as A.S. Rathore and V. Kumar, "Mechanistic Modeling of Preparative Ion-Exchange Chromatography," BioPharm International30 (4) The understanding of the dynamics of chromatography is imperative for the scale-up. This book is a systematic treatment of the general rate models for various forms of liquid chromatography including adsorption, size exclusion, affinity, reversed phase, hydrophobic interaction, and radial flow chromatography.

    6 Modeling of Chromatographic Processes Andreas Seidel-Morgenstern. Introduction Models for Single Chromatographic Columns Equilibrium Stage Models Discontinuous Model According to Craig Continuous Model According to Martin and Synge Derivation of Continuous Mass Balance Equations 1 Model‐Based Preparative Chromatography Process Development in the QbD Paradigm 1 Arne Staby, Satinder Ahuja, and Anurag S. Rathore 1 Motivation Regulatory Context of Preparative Chromatography and Process Understanding 1 Application of Mathematical Modeling to Preparative Chromatography 6 Acknowledgements 8 References 8.


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Modeling for preparative chromatography by Georges Guiochon Download PDF EPUB FB2

Therefore, Modeling for Preparative Chromatography will describe the different mathematical models of chromatography, examine the assumptions on which they are based, consider their properties, and discuss their solutions.

All this will be done from a mathematical analysis point of view, paying considerable attention to the influence of Brand: Academic Press.

Purchase Modeling for Preparative Chromatography - 1st Edition. Print Book & E-Book. ISBN  A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes.

Book contents; Liquid Chromatography. Liquid Chromatography (Second Edition) Preparative chromatography is the best generic method today for the purification of small drugs and valuable chemical components at modeling of preparative liquid chromatography where the aim is to Cited by: 2.

Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides.

• Covers broad aspects of preparative chromatography with a unique combination of. Preparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds.

It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compounds.

The book contains. Preparative chromatography is a versatile methodology that is widely used within the pharmaceutical and fine chemical industry.

For medicinal chemists, chromatography is often the quickest way to obtain gram quantities of each enantiomer of a chiral compound, avoiding the need for enantioselective synthesis in the early stages of drug discovery. Preparative Chromatography - ISBN: Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes.

Preface INTRODUCTION On the Development of Chromatography Focus of. Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process.

The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development.

Fundamentals of Preparative and Nonlinear Chromatography, Second Edition is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration.

Nonlinear chromatography is a field that borders both chemical engineering and physical chemistry. In turn, the theory of nonlinear chromatography is the foundation of preparative chromatography, a separation process that has lately become of considerable interest in the pharmaceutical industry.

Only chromatography is sufficiently flexible and powerful to satisfy the practical requirements. Pei-Lun Chung, Jennifer Galvez Bugayong, Chim Yong Chin, Nien-Hwa Linda Wang, A parallel pore and surface diffusion model for predicting the adsorption and elution profiles of lispro insulin and two impurities in gradient-elution reversed phase chromatography, Journal of Chromatography A, /,52, (), ().

The second edition of Fundamentals of Preparative and Nonlinear Chromatographyis book that discusses all the physico-chemical issues related to linear and nonlinear chromatography.

It summarizes the essential issues involved in thermodynamics (single-component and competitive liquid-solid equilibrium isotherms, influence of the temperature, the pressure, and the mobile phase. Fundamentals of Preparative and Nonlinear Chromatography, Second Edition is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography.

This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug. The main difference between preparative and analytical chromatography is that the main purpose of preparative chromatography is to isolate and purify a reasonable quantity of a specific substance from a sample whereas the main purpose of analytical chromatography is to separate the components of a sample.

Furthermore, preparative chromatography is done in large scale while. Mathematical Modeling and Scale-up of Liquid Chromatography. A monograph written by Tingyue Gu, Dept.

of Chemical & Biomolecular Engineering, Ohio University Published by Springer Verlag, Berlin-New York, (ISBNISBN for ebook).It has a total of pages (vs. pages in the 1 st edition). Original (1 st edition) book information and corrections are. In book: Chromatography, pp of biotechnology, preparative and large scale chromatography becomes more and more popular.

errors in a front velocity chromatography model is quantified. In book: Liquid Chromatography, pp Cite this publication This chapter serves as an introduction to modeling of preparative liquid chromatography where the aim is to improve process.

High-performance liquid chromatography (HPLC) is a versatile separation technology for chemical species.

To learn more about the separation process, we can model it with simulation software. About the HPLC Method. High-performance liquid chromatography (HPLC) is a multistep process designed to separate the chemical components in a mixture. Regulatory Context of Preparative Chromatography and Process Understanding 1.

Application of Mathematical Modeling to Preparative Chromatography 6. Acknowledgements 8. References 8. 2 Adsorption Isotherms: Fundamentals and Modeling Aspects 11 Jørgen M.

Mollerup. Introduction Definitions The Solute Velocity Model 14Pages:. applications such as chiral and preparative separations. £ A Practical Handbook of Preparative HPLC Donald Wellings (Elsevier) This book concentrates on practical, hands-on advice for preparative HPLC from laboratory to process scale.

It will .On the Development of Chromatography Focus of the Book Recommendation to read this Book MODELING AND MODEL PARAMETERS Introduction Models for Single Chromatographic Columns In he joined Merck and has since then been responsible for research and development in the area of preparative chromatography, including the development of new.Nonlinear chromatography is a field that borders both chemical engineering and physical chemistry.

In turn, the theory of nonlinear chromatography is Our Stores Are Open Book Annex Membership Educators Gift Cards Stores & Events HelpPrice: $